Forskningsgruppe for trombose og hemostase

​Forskningsfokus

Sykehuset Østfolds Forskningsgruppen i Trombose og Hemostase ledes av overlege, førsteamanuensis Waleed Ghanima. Gruppen består av 13 medlemmer derav 8 stipendiater. Gruppen fokuserer på klinisk forskning innen venøs tromboembolisme (VTE) og immun trombocytopeni (ITP). Gruppen har et utbredt nasjonalt og internasjonalt samarbeid inklusiv samarbeid med akademiske miljøer og legemiddelindustri og har stort vitenskapelig produksjon innen disse to feltene.
 
Vi fokuserer på diagnostiske og behandlingsstudier samt på  kartlegging av langtidsutkomme og helserelatert livskvalitet etter dyp venetrombose (blodpropp i bein) og lungeemboli (blodpropp i lungene). Vi har dessuten etablert et register for venøs tromboembolisme i Østfold (TROLLS REGISTER). Alle pasienter som behandles for venøs tromboembolisme i Østfold blir registrert i TROLL.
 
Gruppen har en omfattende forskningsaktivitet innen ITP (immunologisk blødersykdom med lave blodplater) og er ledende i Norge innen dette feltet. Gruppen fokuserer på testing av nye behandlingsmetoder for ITP, kartlegging av behandlingsrelaterte bivirkninger og underliggende mekanismer, samt patofysiologiske mekanismer ved ITP.

Gruppe på Facebook:

https://www.facebook.com/groups/148668695684134/


Medlemmer

  • Waleed Ghanima (Forsker, PhD) - Forskningssjefen og overlege, spesialist i indremedisin og blodsykdommer, Sykehuset Østfold. Førsteamnuensis, Institutt for klinisk medisin, UiO.
  • Christina Roaldsnes (Master) – Forskningskoordinator for gruppen, Indremedisinsk avdeling, Sykehuset Østfold.
  •  Mazdak Tavoly (stipendiat) – overlege, spesialist i akuttmedisin, Sahlgrenska universitet sykehus, Gøteborg, Sverige.
  •  Kristin Kornelia Utne (stipendiat) – LIS, Indremedisinsk avdeling, Sykehuset Østfold.
  • Lamya Garabet (stipendiat) – overlege, klinisk kjemi, Akershus universitet sykehus og sykehuset Østfold
  • Synne Frønes (stipendiat) – LIS, Indremedisinsk avdeling, Sykehuset Østfold.
  • Øyvind Jervan (stipendiat) – overlege, Indremedisinsk avdeling, Sykehuset Østfold.
  • Ole Christian Rutherford - (stipendiat) – overlege, spesialist i indremedisin, indremedisinsk avdeling, Sykehuset Østfold.
  • Jostein Gleditsch (stipendiat) – overlege, spesialist i radiologi, avdeling for bildediagnostikk, Sykehuset Østfold.
  • Heidi Hassel Pettersen (Studiemedarbeider, monitor) - sykepleier, indremedisinsk avdeling, Sykehuset Østfold.
  • Eli Førsund (Studiemedarbeider),  trombosesykepleier, indremedisinsk avdeling, Sykehuset Østfold.
  • Camilla Tøvik Jørgensen (Studiemedarbeider), indremedisinsk avdeling, Sykehuset Østfold.
  • Ingvi Holm (monitor) – bioingeniør, indremedisinsk avdeling, Sykehuset Østfold og OUS.

Pågående doktorgradsprosjekter

  • Kristin Utne (2013-   ) Long-term outcomes of deep vein thrombosis; Studies on diagnosis, prevention and impact of post-thrombotic syndrome
  • Mazdak Tavoly (2013 - ) Long-term outcomes of pulmonary embolism
  • Lamya Garabet (2015 -) Effect of thrombopoietin agnosists on coagulation activation and fibrinolysis 
  • Ole Christian Rutherford (2017 -) Effektivitet og sikkerhet ved bruk av orale antikoagulanter
  • Synne Frønes (2017 -) Rivaroxaban for scheduled work-up of DVT – the Rischedule study
  • Jostein Gleditsch (2017 -) The pathophysiology of post- pulmonary embolism syndrome
  • Øivind Jervan (2017 -) Pulmonary rehabilitation to improve exercise capacity after pulmonary embolism - a randomized controlled trial
  • Gudrun Høie (2017- ) – NORFIB -2
  • Jamie York (2017 -) Predictor of response to rituximab and Immunological characterization of ITP

Prosjekter tilknyttet forskningsgruppen


Venous thrombosis 

ITP

  • Population Based Prospective Annual Assessment of Safety of Romiplostim Treatment in Adult Patients with Chronic Idiopathic (Immune) Thrombocytopenic Purpura (ITP) Based on National Health Registry Systems in Denmark, Sweden, and Norway https://www.cristin.no/app/projects/show.jsf?id=399473


Publikasjoner


2017

Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012.

Rørholt M, Ghanima W, Farkas DK, Nørgaard M.

Haematologica. 2017 Jun 1. pii: haematol.2016.157008. doi: 10.3324/haematol.2016.157008. [Epub ahead of print]

PMID: 28572164

 

Scoring Systems for Postthrombotic Syndrome.

Wik HS, Ghanima W, Sandset PM, Kahn SR.

Semin Thromb Hemost. 2017 Jul;43(5):500-504. doi: 10.1055/s-0037-1599142. Epub 2017 May 3.

PMID: 28470653

 

Long-term outcome of patients with solitary plasmacytoma treated with radiotherapy: A population-based, single-center study with median follow-up of 13.7 years.

Barzenje DA, Kolstad A, Ghanima W, Holte H.

Hematol Oncol. 2017 Apr 9. doi: 10.1002/hon.2415. [Epub ahead of print]

PMID: 28393375

 

Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism.

Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; EINSTEIN CHOICE Investigators.

N Engl J Med. 2017 Mar 30;376(13):1211-1222. doi: 10.1056/NEJMoa1700518. Epub 2017 Mar 18.

PMID: 28316279

 

[New direct-acting anticoagulants for cancer patients?].

Dahm AE, Ghanima W.

Tidsskr Nor Laegeforen. 2017 Feb 7;137(3):171-172. doi: 10.4045/tidsskr.17.0008. eCollection 2017 Feb. Norwegian. No abstract available. 

PMID: 28181748

 

Effect of thrombopoietin-receptor agonists on circulating cytokine and chemokine levels in patients with primary immune thrombocytopenia (ITP).

Gudbrandsdottir S, Ghanima W, Nielsen CH, Feng X, Hasselbalch HC, Bussel J.

Platelets. 2017 Jul;28(5):478-483. doi: 10.1080/09537104.2016.1235691. Epub 2016 Nov 7.

PMID: 27819522

 

2016

Health-related quality of life after pulmonary embolism: a cross-sectional study.

Tavoly M, Utne KK, Jelsness-Jørgensen LP, Wik HS, Klok FA, Sandset PM, Ghanima W.

BMJ Open. 2016 Nov 3;6(11):e013086. doi: 10.1136/bmjopen-2016-013086.

PMID:27810979

 

New anticoagulants in combination with antiplatelet agents.

Johansen H, Rutherford OW, Aamodt AH, Russell D, Atar D, Ghanima W.

Tidsskr Nor Laegeforen. 2016 Oct 11;136(18):1543-1546. eCollection 2016 Oct. Review. English, Norwegian. No abstract available. 

PMID: 27731598

 

A nationwide registry study to compare bleeding rates in patients with atrial fibrillation being prescribed oral anticoagulants.

Halvorsen S, Ghanima W, Fride Tvete I, Hoxmark C, Falck P, Solli O, Jonasson C.

Eur Heart J Cardiovasc Pharmacother. 2017 Jan;3(1):28-36. doi: 10.1093/ehjcvp/pvw031. Epub 2016 Sep 27.

PMID: 27680880

 

Response of first line treatment with corticosteroids in a population-based cohort of adults with primary immune thrombocytopenia.

Frederiksen H, Ghanima W.

Eur J Intern Med. 2017 Jan;37:e23-e25. doi: 10.1016/j.ejim.2016.09.001. Epub 2016 Sep 12. No abstract available. 

PMID: 27633568

 

A qualitative study of patient experiences of decentralized acute healthcare services.

Linqvist Leonardsen AC, Del Busso L, Abrahamsen Grøndahl V, Ghanima W, Barach P, Jelsness-Jørgensen LP.

Scand J Prim Health Care. 2016 Sep;34(3):317-24. doi: 10.1080/02813432.2016.1222200. Epub 2016 Aug 25.

PMID: 27559763

 

Health-related quality of life after deep vein thrombosis.

Utne KK, Tavoly M, Wik HS, Jelsness-Jørgensen LP, Holst R, Sandset PM, Ghanima W.

Springerplus. 2016 Aug 8;5(1):1278. doi: 10.1186/s40064-016-2949-z. eCollection 2016.

PMID: 27547653

 

General practitioners' perspectives on referring patients to decentralized acute health care.

Leonardsen AL, Del Busso L, Grøndahl VA, Ghanima W, Jelsness-Jørgensen LP.

Fam Pract. 2016 Dec;33(6):709-714. Epub 2016 Aug 20.

PMID: 27543796

 

Myeloproliferative neoplasms: trends in incidence, prevalence and survival in Norway.

Roaldsnes C, Holst R, Frederiksen H, Ghanima W.

Eur J Haematol. 2017 Jan;98(1):85-93. doi: 10.1111/ejh.12788. Epub 2016 Sep 4.

PMID: 27500783

 

Long-term outcome for patients with early stage marginal zone lymphoma and mantle cell lymphoma.

Barzenje DA, Holte H, Fosså A, Ghanima W, Liestøl K, Delabie J, Kolstad A.

Leuk Lymphoma. 2017 Mar;58(3):623-632. doi: 10.1080/10428194.2016.1204653. Epub 2016 Jul 7.

PMID: 27389974

 

Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial.

Haig Y, Enden T, Grøtta O, Kløw NE, Slagsvold CE, Ghanima W, Sandvik L, Hafsahl G, Holme PA, Holmen LO, Njaaastad AM, Sandbæk G, Sandset PM; CaVenT Study Group.

Lancet Haematol. 2016 Feb;3(2):e64-71. doi: 10.1016/S2352-3026(15)00248-3. Epub 2016 Jan 6.

PMID: 26853645

 

Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis.

Chugh S, Darvish-Kazem S, Lim W, Crowther MA, Ghanima W, Wang G, Heddle NM, Kelton JG, Arnold DM.

Lancet Haematol. 2015 Feb;2(2):e75-81. doi: 10.1016/S2352-3026(15)00003-4. Epub 2015 Feb 5.

PMID: 26687612

 

Risk of arterial thrombotic and venous thromboembolic events in patients with primary chronic immune thrombocytopenia: a Scandinavian population-based cohort study.

Nørgaard M, Cetin K, Maegbaek ML, Kristensen NR, Ghanima W, Bahmanyar S, Stryker S, Christiansen CF.

Br J Haematol. 2016 Aug;174(4):639-42. doi: 10.1111/bjh.13787. Epub 2015 Oct 12. No abstract available. 

PMID: 26456477

 

Development and validation of a tool for patient reporting of symptoms and signs of the post-thrombotic syndrome.

Utne KK, Ghanima W, Foyn S, Kahn S, Sandset PM, Wik HS.

Thromb Haemost. 2016 Jan;115(2):361-7. doi: 10.1160/TH15-04-0318. Epub 2015 Sep 17.

PMID: 26422814

 

2015

Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial.

Ghanima W, Khelif A, Waage A, Michel M, Tjønnfjord GE, Romdhan NB, Kahrs J, Darne B, Holme PA; RITP study group.

Lancet. 2015 Apr 25;385(9978):1653-61. doi: 10.1016/S0140-6736(14)61495-1. Epub 2015 Feb 5.

PMID: 25662413

 

Quality of life after pulmonary embolism: first cross-cultural evaluation of the pulmonary embolism quality-of-life (PEmb-QoL) questionnaire in a Norwegian cohort.

Tavoly M, Jelsness-Jørgensen LP, Wik HS, Roaldsnes C, Sandset PM, Ghanima W.

Qual Life Res. 2015 Feb;24(2):417-25. doi: 10.1007/s11136-014-0779-4. Epub 2014 Aug 14.

PMID: 25120017