Forskningsgruppe Psykisk Helse

Forskningsgruppen har et overordnet mål om å øke kunnskapsgrunnlaget for forebygging og behandling av psykiske lidelser. Pågående prosjekter strekker seg over forskjellige tematiske områder som blant annet samsykelighet ved psykiske lidelser, psykiske lidelser hos eldre og skreddersydd behandling ved psykose og affektive lidelser.

• BE-SAFE: Implementing a patient-centred and evidence-based intervention to reduce BEnzodiazepine and sedative-hypnotic use to improve patient SAFEty and quality of care. Internasjonal multisenter studie som har som hovedmål 1) å øke pasientsikkerhet; 2) fylle kunnskapshull når det gjelder bruk av sovemidler hos eldre pasienter; 3) lage nye, evidensbaserte, pasientnære metoder for å redusere forbruket av sovemidler hos eldre; 4) lage nye, evidensbaserte og dynamiske retningslinjer på europeisk- og lokalt nivå.
• NORSMI generell biobank (https://oslo-universitetssykehus.no/norsmi-biobank): Et nasjonalt samarbeidsprosjekt for å etablere en tematisk forskningsbiobank. Gjennom et bredt samtykke, ønsker man å legge til rette for enklere datainnsamling som kan bli til nytte for fremtidige forskningsprosjekter. Formålet er å skaffe mer kunnskap om årsaker, sykdomsmekanismer og behandling av psykiske lidelser.

• RISK-PATHS: Advancing Violence-Risk Prediction Across the Psychiatric Inpatient Care Continuum

• Socioeconomic position and somatic comorbidity in mental disorders. Tesli M, Hjellvik V, Lergenmuller S, Hjell G, Jangmo A, Haram M, Odsbu I, Ariansen I, Krokstad S, Næss Ø, Kjerpeseth LJ, Nystad W, Bramness JG. Acta Psychiatr Scand. 2026;154(3):234–243. doi:10.1111/acps.70113. PMID: 42189148.
• Mapping cerebellar subregional volumes and heterogeneity in schizophrenia spectrum disorders and violence. Fischer-Vieler T, Rokicki J, Kim M, Leonardsen E, Wolfers T, Bell C, Hjell G, Tesli N, Bang N, Melle I, Andreassen OA, Friestad C, Ringen PA, Haukvik UK. Eur Arch Psychiatry Clin Neurosci. 2026;276(3):1029–1040. doi:10.1007/s00406-025-02081-1. PMID: 40991031.
• Evaluation of a new paracingulate sulcus identification and measurement protocol. de Vareilles H, Mitchell SC, Garrison JR, Wu SCJ, Alvarez-Sanchez L, Thomas R, Kugan S, Al-Manea A, Mamalakis M, Mørch-Johnsen LE, Agartz I, Suckling J, Simons JS, Murray GK. Hum Brain Mapp. 2026;47(8). doi:10.1002/hbm.70574. PMID: 42290380.
• Reassessing asymmetry reduction in psychosis: cingulate folding and gyrification covariance in patients with auditory hallucinations. Wu SCJ, de Vareilles H, Mitchell SC, Al-Manea A, Garrison J, Mamalakis M, Simons JS, Cachia A, Mangin JF, Nerland S, Mørch-Johnsen L, Agartz I, Suckling J, Murray GK. Schizophr Bull. 2026;52(2). doi:10.1093/schbul/sbaf086. PMID: 40476894.
• Workplace violence towards healthcare workers in Norwegian psychiatric inpatient units: a cross-sectional study. Askeli A, Østerås N. Nord J Psychiatry. 2026;80(2):93–101. doi:10.1080/08039488.2025.2599798. PMID: 41474156.
• Evaluation of the Management of Aggression Programme (MAP) in Forensic Units in Norway: A Pilot Study. Senneseth M, Askeli A, Haugen TN. Journal of Forensic Psychology Research and Practice. doi:10.1080/24732850.2026.2647958.
• Robust inference and correlates from genetic associations with personality. Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, … Tesli M … et al. Nature. 2026. doi:10.1038/s41586-026-10992-9. PMID: 42686911.
• Trends in anxiety and depressive symptoms among adults in Norway based on eight population-based surveys from 1995 to 2024. Kirkøen B, Eriksen AMA, Broderstad AR, Høye A, Johansson J, Sivertsen B, Lunde ES, Krokstad S, Aakhus E, Langballe EM, Nilsen TS, Knapstad M, Hansen T, Tesli M, Reneflot A. Discov Ment Health. 2026;6(1):168. doi:10.1007/s44192-026-00522-4. PMID: 42390692.
• Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up. Haram M, Jangmo A, Jaholkowski P, Pasman J, Meijsen J, Shorter JR, Corfield EC, Frei O, Reichborn-Kjennerud T, Buil A, Lu Y, Werge T, Sullivan P, Andreassen OA, Tesli M. Mol Psychiatry. 2026;31(3):1325–1332. doi:10.1038/s41380-025-03243-2. PMID: 40962829.
• Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders. Hoffart Lunding S, Kreis IV, Rødevand L, Aas M, Frogner Werner MC, Torp Johansen I, Elkjær Greenwood Ormerod MB, Reponen E, Hjell G, Ringen PA, Vik Lagerberg T, Melle I, Andreassen OA, Simonsen C, Ueland T, Steen NE. Eur Psychiatry. 2025;68(1). doi:10.1192/j.eurpsy.2025.10106. PMID: 40947592.
• Minor immunomodulatory effects of psychotropics suggested in severe mental disorders: associations of antipsychotics with beta defensin 2, antidepressants with C-reactive protein, and mood stabilizers with soluble interleukin 2 receptor. Ormerod MBEG, Sheikh MA, Ueland T, Hjell G, Rødevand L, Sæther LS, Lunding SH, Johansen IT, Andreou D, Ueland T, Lagerberg TV, Melle I, Djurovic S, Andreassen OA, Steen NE. Eur Psychiatry. 2025;68(1). doi:10.1192/j.eurpsy.2025.10104. PMID: 40936381.
• Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy. Haukvik UK, Wolfers T, Tesli N, Bell C, Hjell G, Fischer-Vieler T, Bang N, Melle I, Andreassen OA, Rasmussen K, Agartz I, Westlye LT, Friestad C, Rokicki J. Transl Psychiatry. 2025 Apr 2;15(1):118. doi:10.1038/s41398-025-03343-1.
• Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders. Ormerod MBEG, Ueland T, Aas M, Hjell G, Rødevand L, Sæther LS, Lunding SH, Johansen IT, Mlakar V, Andreou D, Ueland T, Lagerberg TV, Melle I, Djurovic S, Andreassen OA, Steen NE. Acta Neuropsychiatr. 2025 Jan 23;37:e4. doi:10.1017/neu.2024.62.
• Hypothalamic subunit volumes and relations to violence and psychopathy in male offenders with or without a psychotic disorder. Bell C, Rokicki J, Tesli N, Gurholt TP, Hjell G, Fischer-Vieler T, Bang N, Melle I, Agartz I, Andreassen OA, Ringen PA, Rasmussen K, Dahl H, Friestad C, Haukvik UK. Eur Arch Psychiatry Clin Neurosci. 2024 Feb 14. doi:10.1007/s00406-023-01725-4.
• Mapping care trajectories for hospital-initiated benzodiazepine deprescribing in older adults: a multicentre qualitative study. López-Toribio M, Dalleur O, Adda TR, De Saint-Hubert M, Dikeos D, Tsoutsi V, Callegari E, Wyller TB, Wichniak A, Kaznowski M, Miralles R, Pascual B, Fernández-Maldonado L, Aubert CE, Mooser B, Bolt L, Grimshaw J, Spinewine A, Macq J. BMC Health Serv Res. 2025;25(1):1578. doi:10.1186/s12913-025-13725-2. PMID: 41361424.
• Barriers to discontinuing benzodiazepine receptor agonists in older adults: a survey of older adults across Europe. Shapoval V, de Saint Hubert M, Pétein C, Viaud C, Adda T, Aubert CE, Mooser B, Tsoutsi V, Dikeos D, Fernández Maldonado L, Perez Castejon JM, Wichniak A, Gustavsson K, Wyller TB, Callegari E, Grimshaw J, Presseau J, Patey A, Corachan S, Henrard S, Spinewine A. Age Ageing. 2025;54(12). doi:10.1093/ageing/afaf342. PMID: 41342611.
• Barriers to and enablers of supporting deprescribing benzodiazepines in older adults: a survey of European nonphysician healthcare professionals. Shapoval V, Evrard P, Sibille FX, López-Toribio M, Dalleur O, Aubert CE, Bolt L, Tsoutsi V, Ntafouli M, Fernández Maldonado L, Miralles R, Wichniak A, Gustavsson K, Wyller TB, Callegari E, Grimshaw JM, Presseau J, Henrard S, Spinewine A. Basic Clin Pharmacol Toxicol. 2025;137(4). doi:10.1111/bcpt.70100. PMID: 40898700.
• Equipping physicians for benzodiazepine receptor agonists deprescription in older adults: theory-based development of the BE-SAFE intervention. Sibille FX, Salbert J, Bolt L, Tsoutsi V, Callegari E, Dalleur O, Adda T, Agoritsas T, Berger T, Aubert CE, Dikeos D, Salvà A, Pascual B, Miralles R, Wyller TB, Patey AM, Grimshaw JM, Wichniak A, Spinewine A, de Saint Hubert M. Res Social Adm Pharm. 2025;21(9):714–721. doi:10.1016/j.sapharm.2025.05.002. PMID: 40450448.
• Barriers to Deprescribing Benzodiazepines in Older Adults in a Survey of European Physicians. Shapoval V, de Saint Hubert M, Evrard P, Sibille FX, Aubert CE, Bolt L, Tsoutsi V, Kollia P, Salvà A, Miralles R, Wichniak A, Gustavsson K, Bruun Wyller T, Callegari E, Grimshaw JM, Presseau J, Henrard S, Spinewine A. JAMA Netw Open. 2025 Mar 3;8(3):e2459883. doi:10.1001/jamanetworkopen.2024.59883.
• Early versus adult onset of schizophrenia: an examination of premorbid and current IQ. Calkova T, Vaskinn A, Mørch-Johnsen L, Smelror RE, Jørgensen KN, Wortinger LA, Cervenka S, Collste K, Haatveit B, Mohn C, Myhre AM, Jönsson EG, Steen NE, Andreassen OA, Melle I, Agartz I, Ueland T, Andreou D. Schizophr Res Cogn. 2025;43:100397. doi:10.1016/j.scog.2025.100397. PMID: 41142050.
• Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression. Shorter JR, Pasman JA, Kurvits S, Jangmo A, Naamanka J, Harder A, Hagen E, Kowalec K, Frilander N, Zetterberg R, Meijsen JJ, Gådin JR, Bergstedt J, Xiong Y, Hägg S, Landén M, Rück C, Wallert J, Skalkidou A, Koch E, Akdeniz BC, Frei O; FinnGen; Hovatta I, Reichborn-Kjennerud T, Werge TM, Sullivan PF, Andreassen OA, Tesli M, Lehto K, Buil A, Lu Y. Nat Genet. 2025;57(12):2972–2979. doi:10.1038/s41588-025-02396-8. PMID: 41233554.
• Identification and validation of postpartum depression subtypes: a population-based cohort study. Bauer AE, Jaholkowski P, Lu Y, Guintivano J, Hannigan LJ, Corfield EC, Tesli M, Andreassen OA, Li Y, Reichborn-Kjennerud T, Sullivan PF, Meltzer-Brody S, Havdahl A, Ask H. eClinicalMedicine. 2025;89:103540. doi:10.1016/j.eclinm.2025.103540. PMID: 41140460.
• Educational attainment and mental health outcomes: a within-sibship Mendelian randomization study. Vinueza Veloz MF, Bhatta L, Jones PR, Tesli M, Davey Smith G, Davies NM, Brumpton BM, Næss ØE. Psychol Med. 2025;55. doi:10.1017/S0033291725101736. PMID: 40999803.
• Initiation of Antipsychotics During the First Year After First-Episode Psychosis: A Population-Based Study. Odsbu I, Hamina A, Hjellvik V, Handal M, Haram M, Tesli M, Tanskanen A, Taipale H. Acta Psychiatr Scand. 2025 Apr;151(4):537–547. doi:10.1111/acps.13776.
• A phenomenological approach to violence in schizophrenia spectrum disorders: examination of anomalous self-experience. Fischer-Vieler T, Ringen PA, Kvig E, Bell C, Hjell G, Tesli N, Rokicki J, Bang N, Melle I, Andreassen OA, Friestad C, Johansen R, Svendsen IH, Haukvik UK. The Journal of Forensic Psychiatry & Psychology. 2025;36(2):233–246. doi:10.1080/14789949.2024.2428167.
• Violent Offending in Males With or Without Schizophrenia: A Role for Social Cognition? Vaskinn A, Rokicki J, Bell C, Tesli N, Bang N, Hjell G, Fischer-Vieler T, Haukvik UK, Friestad C. Schizophr Bull. 2024 Apr 30;50(3):663–672. doi:10.1093/schbul/sbad151.
• Sex differences in autonomic adverse effects related to antipsychotic treatment and associated hormone profiles. Johansen IT, Steen NE, Rødevand L, Lunding SH, Hjell G, Ormerod MBEG, Agartz I, Melle I, Lagerberg TV, Nerhus M, Andreassen OA. Schizophrenia (Heidelb). 2024 Jan 6;10(1):6. doi:10.1038/s41537-023-00430-4.
• Toxoplasma gondii infection associated with inflammasome activation and neuronal injury. Andreou D, Steen NE, Mørch-Johnsen L, Jørgensen KN, Wortinger LA, Barth C, Szabo A, O'Connell KS, Lekva T, Hjell G, Johansen IT, Ormerod MBEG, Haukvik UK, Aukrust P, Djurovic S, Yolken RH, Andreassen OA, Ueland T, Agartz I. Sci Rep. 2024 Mar 4;14(1):5327. doi:10.1038/s41598-024-55887-9.
• Solving the enigma: Enhancing faithfulness and comprehensibility in explanations of deep networks. Mamalakis M, Mamalakis A, Agartz I, Mørch-Johnsen LE, Murray GK, Suckling J, Lio P. AI Open. 2025. doi:10.1016/j.aiopen.2025.02.001.
• Increased Herpes simplex virus 1, Toxoplasma gondii and Cytomegalovirus antibody concentrations in severe mental illness. Andreou D, Steen NE, Jørgensen KN, Ueland T, Wortinger LA, Mørch-Johnsen L, Drabløs I, Calkova T, Yolken RH, Andreassen OA, Agartz I. Transl Psychiatry. 2024 Dec 18;14(1):498. doi:10.1038/s41398-024-03198-y.
• Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia. Andreou D, Jørgensen KN, Nerland S, Calkova T, Mørch-Johnsen L, Smelror RE, Wortinger LA, Lundberg M, Bohman H, Myhre AM, Jönsson EG, Andreassen OA, Agartz I. Sci Rep. 2024 Oct 1;14(1):22755. doi:10.1038/s41598-024-73322-x.
• Current Auditory Hallucinations Are Not Associated With Specific White Matter Diffusion Alterations in Schizophrenia. Nerland S, Slapø NB, Barth C, Mørch-Johnsen L, Jørgensen KN, Beck D, Wortinger LA, Westlye LT, Jönsson EG, Andreassen OA, Maximov II, Geier OM, Agartz I. Schizophr Bull Open. 2024 Apr 17;5(1):sgae008. doi:10.1093/schizbullopen/sgae008. eCollection 2024 Jan.
• Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio. Jørgensen KN, Nerland S, Slapø NB, Norbom LB, Mørch-Johnsen L, Wortinger LA, Barth C, Andreou D, Maximov II, Geier OM, Andreassen OA, Jönsson EG, Agartz I. Psychol Med. 2024 Jul;54(10):2369–2379. doi:10.1017/S0033291724000503. Epub 2024 Apr 2.
• Hypothalamic Subunit Volumes in Schizophrenia and Bipolar Spectrum Disorders. Ruggeri A, Nerland S, Mørch-Johnsen L, Jørgensen KN, Barth C, Wortinger LA, Andreou D, Andreassen OA, Agartz I. Schizophr Bull. 2024 Apr 30;50(3):533–544. doi:10.1093/schbul/sbad176.

• Avdeling for psykisk helse, Folkehelseinstituttet
• Institutt for klinisk medisin, Universitetet i Oslo
• Forskningsgruppe for legemiddelbruk hos eldre, Geriatrisk forskningsenhet, OUS
• Department of psychiatry, University of Oxford
• TIPS Sør-Øst, Regional kompetansetjeneste for tidlig intervensjon ved psykose
• NORSMI, Norwegian Research Network in Severe Mental Disorders

For more information, please contact the group leader gabriela.hjell@so-hf.no