Medlemmer med beskrivelse av rolle
Navn | Rolle | Tittel |
Lars Grøvle | Gruppeleder og forsker | Overlege PhD |
Eivind Hasvik | Forsker | Fysioterapeut PhD |
Anne Julsrud Haugen | Forsker | Overlege PhD |
Christian Høili | Forsker | Overlege |
Jing Lisa Li Lorentsen | Forsker | Overlege
|
Nasjonale og regionale samarbeid og nettverk:
- Forsknings- og formidlingsenheten for muskelskjeletthelse (FORMI)
- Forskningssenter for behandling innen revmatologi og muskelskjelettsykdommer (REMEDY)
- Div avdelinger for revmatologi og fysikalsk medisin og rehabilitering
Forskningsfokus
Klinisk forskning på ledd- og rygglidelser
Oversikt over prosjekter i forskningsgruppen og hva som er formålet med hvert prosjekt
NIS | Nytten av NSAIDs ved isjias |
pBMES | Sykdomsutvikling ved primært benmargsødemsyndrom (BMES) |
Back to basic | Nytten av Infliximab ved ryggsmerter og Modicforandringer |
Arctic forward | Sykdomsforløpet ved leddgikt |
BMES review | Terminologi og sykdomsforløp ved BMES og transitorisk osteoporose |
GCAPTAIN | Secukinumab ved kjempecellearteritt (Novartis)
|
Pågående doktorgradsprosjekter
Publikasjoner
1. Kristoffersen, P.M., et al., Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain: Subgroup Analyses of a Randomised Trial (the AIM Study). Spine (Phila Pa 1976), 2023. 48(3): p. 147-154 DOI: 10.1097/brs.0000000000004513.
2. Bråten, L.C.H., et al., Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study). J Pain Res, 2023. 16: p. 1713-1724 DOI: 10.2147/jpr.S406079.
3. Vigeland, M.D., et al., Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement. Sci Rep, 2022. 12(1): p. 215 DOI: 10.1038/s41598-021-04189-5.
4. Haukeland-Parker, S., et al., Cross-cultural adaptation and validation of the Norwegian version of the Leicester Cough Questionnaire in chronic obstructive pulmonary disease. Physiother Theory Pract, 2022. 38(12): p. 2175-2184 DOI: 10.1080/09593985.2021.1911012.
5. Hasvik, E., A.J. Haugen, and L. Grøvle, Symptom descriptors and patterns in lumbar radicular pain caused by disc herniation: a 1-year longitudinal cohort study. BMJ Open, 2022. 12(12): p. e065500 DOI: 10.1136/bmjopen-2022-065500.
6. Hasvik, E., et al., Strategies to manage auxiliary pain medications in chronic pain trials: a topical review. Eur J Clin Pharmacol, 2022. 78(9): p. 1377-1384 DOI: 10.1007/s00228-022-03355-6.
7. Grøvle, L., et al., NSAIDs in sciatica (NIS): study protocol for an investigator-initiated multicentre, randomized placebo-controlled trial of naproxen in patients with sciatica. Trials, 2022. 23(1): p. 493 DOI: 10.1186/s13063-022-06441-3.
8. Grøvle, L., E. Hasvik, and A.J. Haugen, Letter to the editor regarding "Minimally-invasive percutaneous treatments for low back pain and leg pain: a randomized controlled study of thermal disc decompression versus mechanical percutaneous disc decompression" by Fasoli et al. Spine J, 2022. 22(12): p. 2082 DOI: 10.1016/j.spinee.2022.08.003.
9. Grøvle, L., E. Hasvik, and A.J. Haugen, Impact of rescue medication in placebo-controlled trials of pharmacotherapy for neuropathic pain and low back pain. Pain, 2022. 163(3): p. e417-e425 DOI: 10.1097/j.pain.0000000000002380.
10. Dagestad, M.H., et al., Apparent diffusion coefficient values in Modic changes - interobserver reproducibility and relation to Modic type. BMC Musculoskelet Disord, 2022. 23(1): p. 695 DOI: 10.1186/s12891-022-05610-4.
11. Bråten, L.C.H., et al., Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain. J Clin Epidemiol, 2022. 151: p. 75-87 DOI: 10.1016/j.jclinepi.2022.07.012.
12. Syversen, S.W., et al., Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial. Jama, 2021. 326(23): p. 2375-2384 DOI: 10.1001/jama.2021.21316.
13. Lillegraven, S., et al., Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial. Jama, 2021. 325(17): p. 1755-1764 DOI: 10.1001/jama.2021.4542.
14. Lie, M.U., et al., Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC. Front Genet, 2021. 12: p. 757632 DOI: 10.3389/fgene.2021.757632.
15. Kristoffersen, P.M., et al., Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial. Eur Radiol, 2021. 31(6): p. 4285-4297 DOI: 10.1007/s00330-020-07542-w.
16. Hasvik, E., A.J. Haugen, and L. Grøvle, Pinprick and Light Touch Are Adequate to Establish Sensory Dysfunction in Patients with Lumbar Radicular Pain and Disc Herniation. Clin Orthop Relat Res, 2021. 479(4): p. 651-663 DOI: 10.1097/corr.0000000000001605.
17. Stynes, S., et al., New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica. Eur J Pain, 2020. 24(1): p. 171-181 DOI: 10.1002/ejp.1475.
18. Norli, E.S., et al., Joint Distribution and Two-Year Outcome in 347 Patients With Monoarthritis of Less Than Sixteen Weeks' Duration. Arthritis Care Res (Hoboken), 2020. 72(5): p. 705-710 DOI: 10.1002/acr.23334.
19. Jelsness-Jørgensen, L.P., L. Grøvle, and A. Julsrud Haugen, Association between vitamin D and fatigue in patients with rheumatoid arthritis: a cross-sectional study. BMJ Open, 2020. 10(2): p. e034935 DOI: 10.1136/bmjopen-2019-034935.
20. Grøvle, L., E. Hasvik, and A.J. Haugen, Rescue and concomitant analgesics in placebo-controlled trials of pharmacotherapy for neuropathic pain and low back pain. Pain, 2020. 161(1): p. 3-10 DOI: 10.1097/j.pain.0000000000001690.
21. Grotle, M., et al., Cost-utility analysis of antibiotic treatment in patients with chronic low back pain and Modic changes: results from a randomised, placebo-controlled trial in Norway (the AIM study). BMJ Open, 2020. 10(6): p. e035461 DOI: 10.1136/bmjopen-2019-035461.
22. Gjefsen, E., et al., The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial. BMC Musculoskelet Disord, 2020. 21(1): p. 698 DOI: 10.1186/s12891-020-03720-5.
23. Bråten, L.C.H., et al., Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study. BMC Musculoskelet Disord, 2020. 21(1): p. 368 DOI: 10.1186/s12891-020-03381-4.
24. Bråten, L.C.H., et al., Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study). BMC Musculoskelet Disord, 2020. 21(1): p. 458 DOI: 10.1186/s12891-020-03422-y.
25. Hasvik, E., et al., Up-regulation of circulating microRNA-17 is associated with lumbar radicular pain following disc herniation. Arthritis Res Ther, 2019. 21(1): p. 186 DOI: 10.1186/s13075-019-1967-y.
26. Hasvik, E., et al., Cross-cultural Adaptation and Validation of the Norwegian Short-form McGill Pain Questionnaire-2 in Low Back-related Leg Pain. Spine (Phila Pa 1976), 2019. 44(13): p. E774-e781 DOI: 10.1097/brs.0000000000002976.
27. Hasvik, E., A.J. Haugen, and L. Grøvle, Call for Caution in Using the Pain DETECT Questionnaire for Patient Stratifi cation Without Additional Clinical Assessments: Comment on the Article by Soni et al. Arthritis Rheumatol, 2019. 71(7): p. 1201-1202 DOI: 10.1002/art.40804.
28. Grøvle, L., et al., The Rates of LSS Surgery in Norwegian Public Hospitals: A Threefold Increase From 1999 to 2013. Spine (Phila Pa 1976), 2019. 44(6): p. E372-e378 DOI: 10.1097/brs.0000000000002858.
29. Grotle, M., et al., Lumbar spine surgery across 15 years: trends, complications and reoperations in a longitudinal observational study from Norway. BMJ Open, 2019. 9(8): p. e028743 DOI: 10.1136/bmjopen-2018-028743.
30. Fjeld, O.R., et al., Complications, reoperations, readmissions, and length of hospital stay in 34 639 surgical cases of lumbar disc herniation. Bone Joint J, 2019. 101-b(4): p. 470-477 DOI: 10.1302/0301-620x.101b4.Bjj-2018-1184.R1.
31. Bråten, L.C.H., et al., Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial. Bmj, 2019. 367: p. l5654 DOI: 10.1136/bmj.l5654.
32. Brinkmann, G.H., et al., Treat to target strategy in early rheumatoid arthritis versus routine care - A comparative clinical practice study. Semin Arthritis Rheum, 2019. 48(5): p. 808-814 DOI: 10.1016/j.semarthrit.2018.07.004.
33. Hasvik, E., et al., Assessing neuropathic pain in patients with low back-related leg pain: Comparing the painDETECT Questionnaire with the 2016 NeuPSIG grading system. Eur J Pain, 2018. 22(6): p. 1160-1169 DOI: 10.1002/ejp.1204.
34. Storheim, K., et al., Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial. Trials, 2017. 18(1): p. 596 DOI: 10.1186/s13063-017-2306-8.
35. Norli, E.S., et al., Diagnostic spectrum and 2-year outcome in a cohort of patients with very early arthritis. RMD Open, 2017. 3(2): p. e000573 DOI: 10.1136/rmdopen-2017-000573.
36. Grøvle, L. and A.J. Haugen, Denosumab in bone marrow oedema syndrome. Injury, 2017. 48(6): p. 1275-1276 DOI: 10.1016/j.injury.2017.04.005.
37. Brinkmann, G.H., et al., Disease Characteristics and Rheumatoid Arthritis Development in Patients with Early Undifferentiated Arthritis: A 2-year Followup Study. J Rheumatol, 2017. 44(2): p. 154-161 DOI: 10.3899/jrheum.160693.
38. Brinkmann, G.H., et al., Role of erosions typical of rheumatoid arthritis in the 2010 ACR/EULAR rheumatoid arthritis classification criteria: results from a very early arthritis cohort. Ann Rheum Dis, 2017. 76(11): p. 1911-1914 DOI: 10.1136/annrheumdis-2017-211350.
39. Haavardsholm, E.A., et al., Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial. Bmj, 2016. 354: p. i4205 DOI: 10.1136/bmj.i4205.
40. Haugen, A.J., et al., [A man in his 40s with pain in his right thigh and knee]. Tidsskr Nor Laegeforen, 2016. 136(18): p. 1553-1555 DOI: 10.4045/tidsskr.15.1151.
41. Haugen, A.J., et al., Pain-related fear and functional recovery in sciatica: results from a 2-year observational study. J Pain Res, 2016. 9: p. 925-931 DOI: 10.2147/jpr.S115003.
42. Aga, A.B., et al., First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach. Ann Rheum Dis, 2016. 75(8): p. 1444-51 DOI: 10.1136/annrheumdis-2015-207572.
43. Aga, A.B., et al., Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach. RMD Open, 2016. 2(2): p. e000325 DOI: 10.1136/rmdopen-2016-000325.